• Pregnenolone (Micronized): A bioavailable form of the parent steroid hormone that supports adrenal, reproductive, and neurological function.*[1]
• Neurosteroid Activity: Synthesized in the brain and peripheral nervous system, pregnenolone modulates GABA and NMDA receptors and influences neuroplasticity via BDNF.*[2,3,4,5]
• Hormone Precursor: Serves as the first step in the synthesis of key hormones including cortisol and sex hormones, influencing metabolism, immune balance, and reproductive health.*[1,6]
• Cognitive and Mood Support: Clinical trials suggest pregnenolone supplementation supports focus, working memory, and mood, particularly in populations under cognitive or emotional strain.*[7,8,9]
• Age-Related Optimization: Endogenous pregnenolone production decreases with age. Pregnenolone supports mental stamina and resilience.*[6,10]
• Clinical Dosing Evidence: Human studies have used 30–500 mg daily to support quality of life, attention, and cognitive performance in certain populations.*[7,8,9]