Tricycline® delivers traditional and evidence-based botanicals including berberine, artemisinin, citrus seed extract, black walnut, and sweet wormwood to support a healthy intestinal microbiome and digestive function.* Ideal for complementary use with probiotics.* The grapefruit seed extract we use has been shown via third-party testing to be free of the potentially dangerous contaminants triclosan, benzethonium chloride, and benzalkonium chloride.*
Support Balanced Microbial Ecology in the GI Tract*
What It Does
Tricycline® is a microbial balancing formula designed to support a healthy gastrointestinal (GI) microbiome.* It complements probiotic use by promoting a balanced microbial environment and healthy intestinal function.* This unique botanical blend offers targeted support for digestive health and intestinal microbial ecology.*
How It Works
• Berberine: A bioactive alkaloid that supports digestive function and modulates the gut microbiome toward a favorable balance, encouraging short-chain fatty acid production and healthy mucosal integrity.*[1]
• Artemisinin (from Artemisia annua): A highly concentrated form of sweet wormwood shown to influence GI microbial composition via multiple mechanisms; independently tested for cell activity and potency via third-party HPLC.*[4]
• Citrus Seed Extract (Grapefruit): Contains polyphenols such as naringenin, which may influence gut motility and intestinal barrier function while promoting microbial diversity in the proximal colon.*[5-7]
• Black Walnut Hulls: Traditionally used to support skin and GI health; a source of tannins and antioxidant compounds with microbial-modulating effects.*[8]
• Sweet Wormwood (Artemisia annua): A traditional herb used for microbial balance, providing additional phytochemical support to the artemisinin content.*
Who It’s For
Ideal for individuals seeking additional gastrointestinal support beyond probiotics, particularly those with concerns about microbial balance, gut motility, or intestinal immune tone.*
Special Features
Tricycline® features independently verified artemisinin potency, third-party HPLC testing, and a comprehensive blend of traditional and modern microbiome-focused botanicals. It is formulated without unnecessary fillers or allergens.
References
1. Xu X, et al. Biomed Pharmacother. 2021;133:110984. doi:10.1016/j.biopha.2020.110984
2. Caliceti C, et al. Curr Med Chem. 2016;23(14):1460-76.
3. Zhang L, et al. Front Cell Infect Microbiol. 2021;10:588517. doi:10.3389/fcimb.2020.588517
4. Golenser J, et al. Int J Parasitol. 2006;36(14):1427-41.
5. Sost MM, et al. Nutrients. 2021;13(11):3915. https://doi.org/10.3390/nu13113915
6. Wu L, et al. Foods. 2024;13(16):2520. https://doi.org/10.3390/foods13162520
7. Stevens Y, et al. Nutrients. 2019;11(7):1464. https://doi.org/10.3390/nu11071464
8. Jahanban-Esfahlan A, et al. Int J Mol Sci. 2019;20(16):3920. doi:10.3390/ijms20163920
9. Wenzel J, et al. Food Sci Nutr. 2016;5(2):223-32.
Suggested use:
As a dietary supplement, take 1 capsule three times daily with meals, or as directed by a healthcare practitioner.
Warning:
If you are pregnant or lactating, have any health condition or are taking any medication, consult your healthcare practitioner before use.
Store in a cool, dry place, tightly capped, away from light. Keep out of the reach of children. Use only if safety seal is intact. Variations in product color may occur.
Consuming this product can expose you to lead which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov/food
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