Trimethylglycine (TMG) supports methylation, liver health, and homocysteine metabolism while acting as a cellular osmolyte for stress resilience.* TMG assists homocysteine to be metabolized into methionine, resulting in the production of DMG (dimethylglycine).* The two major functions of TMG in humans are as an osmolyte to protect cells under stress and as a methyl-group donor.*
Supports Healthy Methylation and Cellular Resilience*
What It Does
Trimethylglycine (TMG), also known as betaine, supports normal homocysteine metabolism and helps maintain healthy methylation pathways. It contributes to liver and kidney cellular health while promoting osmotic balance and protecting cellular structures under stress.*
How It Works
• Trimethylglycine (TMG): provides methyl groups to convert homocysteine to methionine via the enzyme betaine homocysteine methyltransferase (BHMT), especially active in the liver and kidneys.*[1]
• Bypasses MTHFR limitations: offering an alternative methylation route for individuals with the 677TT polymorphism or functional folate needs.*[2]
• Supports healthy homocysteine metabolism.*[3-4]
• Effective at lower doses with benefits observed at lower dietary intake levels of betaine.*[5]
• Acts as a cellular osmolyte protecting proteins, enzymes, and DNA while improving cellular fluid retention and resilience to osmotic stress which is particularly supportive for kidney cells.*[6][2]
Who It’s For
Ideal for individuals seeking to support cardiovascular and liver health, methylation balance, or homocysteine support, especially those with genetic polymorphisms affecting folate metabolism.*
Special Features
Offers dual-action support for methylation and cellular osmoprotection, making it uniquely valuable for stress-prone tissues like the liver and kidneys.*
References
1. Obeid R. Nutrients. 2013;5(9):3481–95.
2. Arumugam MK et al. Biology. 2021;10(6):456. doi:10.3390/biology10060456
3. Steenge GR et al. J Nutr. 2003;133(5):1291–5.
4. McRae MP. J Chiropr Med. 2013;12(1):20–5.
5. Olthof MR et al. J Nutr. 2003;133(12):4135–8.
6. Craig S. Am J Clin Nutr. 2004;80(3):539–49
Suggested use:
As a dietary supplement, take 1 capsule twice daily before meals, or as directed by a healthcare practitioner.
Warning:
If you are pregnant or lactating, have any health condition or are taking any medication, consult your healthcare practitioner before use.
Store in a cool, dry place, tightly capped, away from light. Keep out of the reach of children. Use only if safety seal is intact. Variations in product color may occur.
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