Metabolic Maintenance SAMe + Cofactors new look bottle front label with trusted formula messaging for methylation and mood support

Supplement Facts panel for SAMe + Cofactors showing vitamin B6, folate, vitamin B12, magnesium, calcium, and SAMe

SAMe + Cofactors ingredient benefits infographic highlighting S-adenosyl methionine support for methylation processes and healthy neurotransmitter formation

Suggested use panel for SAMe + Cofactors showing one to two capsules daily between meals or as directed by a healthcare practitioner

SAMe + Cofactors key benefits infographic highlighting balanced mood support, healthy neurotransmitter formation, and homocysteine conversion back to SAMe

SKU 00156

Metabolic Maintenance® SAMe + Cofactors 200 mg

Name: Metabolic Maintenance® SAMe + Cofactors 200 mg
Brand: Metabolic Maintenance
SKU: 00156
Price: 73.00 USD
Availability: InStock

SAMe with Cofactors provides support for mood, liver, and methylation health.* Combining SAMe with active B-vitamins (B6, methylfolate, and methylcobalamin), this formula promotes neurotransmitter synthesis, detoxification, and cellular energy balance.*

$73.00

Tax excluded.

Quantity:

Ingredients

Vitamin B-6: 2 mg
Folate: 333 mcg DFE
Vitamin B-12: 500 mcg
Calcium: 27 mg
Magnesium: 10 mg
SAMe: 200 mg

Other Ingredients

Suggested Use

One to two (1-2) capsules daily between meals, or as directed by a healthcare professional.

Metabolic Maintenance® SAMe + Cofactors 200 mg

$73.00

What It Does

SAMe with Cofactors provides targeted nutritional support for balanced mood, healthy liver function, and optimal methylation activity.* This comprehensive formula combines S-adenosyl-L-methionine (SAMe) with essential methyl donors and cofactors—vitamin B6, active folate, and methylcobalamin to help sustain neurotransmitter synthesis, cellular detoxification, and energy metabolism.*

How It Works

SAMe (S-adenosyl-L-methionine) — Serves as a universal methyl donor that supports serotonin, dopamine, and norepinephrine metabolism while promoting liver detoxification and phospholipid synthesis.* [1,2]

L-5-Methylfolate — Provides the biologically active form of folate, essential for the remethylation of homocysteine and production of neurotransmitters involved in mood regulation.* [3,4]

Vitamin B12 (as methylcobalamin) — Works with folate and SAMe to maintain methylation balance, support nerve integrity, and aid in red blood cell formation.* [4,5]

Vitamin B6 (as pyridoxal-5′-phosphate) — Functions as a coenzyme in amino acid metabolism and assists in the synthesis of serotonin, GABA, and dopamine.* [5]

Who It's For

Ideal for individuals seeking support for mood balance, cognitive clarity, and liver function, or those with increased methylation demands due to stress, genetic polymorphisms, or other situations.*

Special Features

Features the active, bioavailable forms of B-vitamins including methylcobalamin, L-5-MTHF, and P-5-P for immediate utilization, with 400 mg of SAMe to optimize methylation efficiency. Free of gluten, soy, and artificial excipients, and manufactured under strict quality standards for purity and strength.*

References

1. Baden KER, et al. Nutrients. 2024;16(18):3148. doi:10.3390/nu16183148
2. Baden K, et al. Nutrients. 2024;16(21):3668. doi:10.3390/nu16213668
3. Papakostas GI, et al. Am J Psychiatry. 2012;169(12):1267-74.
4. Reynolds E. Lancet Neurol. 2006;5(11):949-60.
5. Kennedy DO. Nutrients. 2016;8(2):68.

Additional Information

Supports mood, liver, and methylation health through synergistic nutrient support.*

Metabolic Maintenance® SAMe + Cofactors 200 mg

What It Does

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