L-Ornithine-L-Aspartate (LOLA) supports healthy nitrogen metabolism by promoting the natural detoxification of ammonia through the urea cycle and glutamine synthesis pathways.* By providing key amino acids, LOLA helps maintain liver function, ammonia clearance, and metabolic balance, especially during times of increased nitrogen stress.* Each serving delivers 3 grams of clinically relevant LOLA in a versatile powdered form.*
As a dietary supplement, take 1 rounded teaspoon three times daily, or as directed by a healthcare practitioner.
Warning:
If you are pregnant or lactating, have any health condition or are taking any medication, consult your healthcare practitioner before use.
Store in a cool, dry place, tightly capped, away from light. Keep out of the reach of children. Use only if safety seal is intact. Variations in product color may occur.
Ingredients:
Serving Size: 1 rounded teaspoon Servings Per Container: approx. 33
Amount per serving:
L-Ornithine-L-Aspartate: 3 g
Promotes Healthy Ammonia Clearance and Liver-Supportive Nitrogen Metabolism*
What It Does
L-Ornithine-L-Aspartate (LOLA) supports healthy nitrogen metabolism by promoting the natural detoxification of ammonia through the urea cycle and glutamine synthesis pathways.* This clinically relevant formula helps maintain liver function, ammonia clearance, and overall metabolic balance, particularly during periods of increased nitrogen stress.*
How It Works
• L-Ornithine activates carbamoyl phosphate synthetase, the rate-limiting enzyme of the urea cycle, enhancing the conversion of ammonia to urea in periportal hepatocytes for excretion.*[1]
• L-Aspartate serves as a substrate in transamination reactions and contributes to glutamine synthesis, aiding in ammonia removal via non-urea pathways.*[3]
• Glutamine Synthetase Activation in perivenous hepatocytes, skeletal muscle, and brain tissue facilitates an additional mechanism for reducing circulating ammonia.*[3]
• Clinical Research supports the use of oral LOLA in improving ammonia metabolism and mental state, especially in individuals with hepatic metabolic burden.*[4]
• Meta-Analysis Findings indicate that LOLA supplementation significantly supports detoxification pathways.*[4,5]
Who It’s For
Designed for individuals seeking targeted support for ammonia clearance and liver-related nitrogen metabolism, or those seeking to ease metabolic stress, support a high protein diet, or support detoxification.*
Special Features
Each serving delivers 3 grams of high-quality LOLA in an easy-to-use powdered format, allowing flexible dosing and alignment with clinical trial protocols.*
References
1. Weiner ID, et al. Clin J Am Soc Nephrol. 2015;10(8):1444–1458.
2. Butterworth RF. Metab Brain Dis. 2020;35(1):75–81.
3. Butterworth RF. Drugs R D. 2021;21(2):123–132.
4. Butterworth RF, Canbay A. Dig Dis. 2019;37(1):63–68.
