Featured
Peer-Reviewed Publication: Integrative Framework for Thyroid & Endocrine Resilience
When Cortisol Loses Its Rhythm: Burnout, Fatigue, and the Case for Adrenal Resilience
Cortisol is not meant to be constant. Under healthy conditions, it follows a daily rhythm that supports alertness and energy availability earlier in the day, then gradually declines to allow for rest and repair. This rhythm reflects an intact feedback system within the HPA axis, enabling cortisol to rise when stress requires it and fall when the demand passes. [1]
Cortisol dysregulation reflects changes in central signaling, feedback sensitivity, hormone availability, and tissue responsiveness, and not a simple excess or deficiency. Treating cortisol as a number to correct risks pushing the system further from balance rather than restoring adaptive range.
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Adrenal Glandular Supplements: Mechanisms, Evidence, and When They May Be Helpful
Long before hormone assays and isolated compounds were available, clinicians explored ways to nourish organs directly, guided by the observation that tissues contain unique biological components that support systemic function.* Today, adrenal glandular supplements are best understood not as hormone replacements, but as complex nutritional matrices that provide tissue-associated compounds which may support the body’s adaptive response to stress.*
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