Stress, thyroid function, and the brain’s GABA system form a tightly connected feedback loop. Because each system affects the others, disruptions can create a cycle of stress sensitivity, cognitive fog, and emotional imbalance. Understanding this interconnected network allows clinicians and patients to approach symptoms more holistically—focusing on stress regulation, thyroid support, and nervous system balance to restore harmony across the entire neuroendocrine system.
Featured
Peer-Reviewed Publication: Integrative Framework for Thyroid & Endocrine Resilience
Allergy Research Group® (ARG), a leader in evidence-based nutritional supplements, today announced the publication of a new peer-reviewed scientific paper in the International Journal of Molecular Sciences.
Read now
Fatigue and Coronary Artery Disease: Links to Thyroid Hormone and Cortisol Regulation
Fatigue is one of the most common, yet least understood symptoms experienced by people with coronary artery disease (CAD). For many patients, this fatigue becomes the symptom that most limits daily life, even when cardiac function appears stable. This disconnect has often lead medical providers to ask the question of could fatigue in coronary artery disease reflect not only cardiac impairment, but also underlying shifts in hormonal systems that regulate energy, stress, and recovery? New data suggests that fatigue may in fact be a signal of how the body is allocating energy under strain rather than a byproduct of deconditioning or mood.
Read now
The Role of Cortisol in Dampening Thyroid Function and Flattening Mood
Cortisol level do not merely respond to thyroid dysfunction. It feeds back into the system. Elevated cortisol can suppress thyroid signaling at multiple levels of the HPT axis, further reducing metabolic output. Over time, this creates a reinforcing loop. Lower thyroid hormone availability raises cortisol. Sustained cortisol elevation further dampens thyroid signaling, which leads to emotional flattening, decreased motivation, muted pleasure, slowed thinking, and a more narrow emotional range.
Read now
Holy Basil and Stress Resilience: Clinical Evidence for Supporting Cortisol, Sleep, and Recovery*
Traditional use of holy basil does not utilize it as a stimulant or sedative.* Instead, it is viewed as a botanical that helps the body maintain balance amid physical, emotional, and environmental stressors.* [1] Recent research now offers clearer insight into how it may support stress resilience, cortisol dynamics, and the conditions that allow restorative sleep to emerge.* [1][2]
Read now
Pantothenic Acid (Vitamin B5), Energy Metabolism, and Adrenal Stress Adaptation*
Stress is not simply a hormonal signal, it is an energetically demanding physiological state. The ability to respond to stress, sustain output, and return toward baseline depends on whether cells, particularly those within the adrenal glands, have sufficient metabolic capacity to meet the demands placed upon them. Pantothenic acid can be implemented as a foundational nutrient that supports the body’s ability to meet demand and recover afterward, rather than as a quick fix or hormonal modifier.*
Read now
The HPA–Thyroid–GABA Connection
Read now
Cortisol and Selected Botanicals
Adaptogens like ashwagandha, magnolia, and lemon balm help balance cortisol and enhance resilience to stress. Learn how these botanicals support calm, focus, and well-being.
Read now
