Stress, thyroid function, and the brain’s GABA system form a tightly connected feedback loop. Because each system affects the others, disruptions can create a cycle of stress sensitivity, cognitive fog, and emotional imbalance. Understanding this interconnected network allows clinicians and patients to approach symptoms more holistically—focusing on stress regulation, thyroid support, and nervous system balance to restore harmony across the entire neuroendocrine system.
Laura Lewis, MS
Finding the right multivitamin can be a game changer for your overall health, but with so many options, it can be tough to know which one is best suited to your specific needs.
In this article, we’ll compare some of our top multivitamin options, including The Big One® (with and without iron), The Big One® Plus, Basic Maintenance®, FemOne™, Little One™, Balanced Response™, and Metabolic Detox Complete® Powder, to help you choose the best fit for your needs.
Why Choose a Methylated Multivitamin?
One of the main benefits of choosing a multivitamin with methylated B vitamins, such as L-methylfolate and methylcobalamin (B12), is that these vitamins are already in their active forms, making them more easily absorbed by the body. This is especially important for individuals with certain genetic mutations, like MTHFR, that make it difficult to process non-methylated vitamins.* [1] Methylated multivitamins can help support energy production, cognitive function, cardiovascular health, and more. [1,2]
Let’s take a closer look at the different multivitamin options and who they’re best for.
1. The Big One® (with and without Iron) and The Big One® Plus
The Big One® is popular multivitamin, offering a potent and comprehensive blend of essential vitamins and minerals, including methylated B vitamins like L-methylfolate and methylcobalamin. This formula is designed for individuals looking for full-spectrum nutritional support in just one capsule per day.
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With Iron: This option is perfect for individuals who have higher iron needs, such as menstruating women or people seeking to improve their iron status.
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Without Iron: Ideal for those who do not need extra iron, such as many postmenopausal women or men. Excess iron can sometimes be harmful if taken unnecessarily, so this option allows for the benefits of a robust multivitamin without the added iron.
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Plus (Without Iron): Contains an added 2000 IU of vitamin D-3. Those who spend little time exposed to the sun or are seeking to raise their vitamin D status for other reasons could likely benefit from added vitamin D supplementation. Vitamin D benefits bone health, immune function and mood.* [3]
Whether you need iron, vitamin D, or neither, “The Big One®” methylated multivitamins are excellent choices for those seeking simplicity without sacrificing comprehensive nutrient support.
2. Basic Maintenance®
Basic Maintenance® multivitamin is a simple yet effective option for those looking for foundational nutritional support.* It is our only encapsulated option that contains calcium and magnesium making it a great fit for those who want to cover their nutritional bases with one product. This product includes a balance of essential vitamins and minerals, including methylated B vitamins, making it a great choice for everyday wellness.*
Basic Maintenance® is a great choice if you are seeking a nutritional foundation to build upon with other single-nutrient or herbal supplements for a customized supplement regimen. But always be sure to confirm this with a healthcare practitioner before combining formulas.
Alternatively, if you’re someone who prefers a straightforward multivitamin with less potent doses than The Big One®, Basic Maintenance® may be all you need. It’s perfect for maintaining general health and wellness, particularly for individuals with no specific health goals and average nutrient needs.*
3. FemOne™
FemOne™ is a comprehensive multivitamin designed specifically for women’s unique nutritional needs through their menstruating or child-bearing years. Folate and iron are two top considerations for this age group and this product delivers highly bioavailable forms of both. This formula provides essential vitamins and minerals, including methylated B vitamins, along with nutrients that support balanced immune responses, hormonal health, fertility and gestation, and bone strength.*
FemOne™ is an excellent choice for women seeking targeted multivitamin support for overall well-being, with additional ingredients tailored to support women’s health.*.
4. Little One™
For younger individuals or those who have a lighter nutrient requirement, the Little One™ multivitamin offers all the essential vitamins and minerals, including methylated B vitamins, but in smaller doses. This formula is particularly suitable for older children, teens, or individuals with a lower daily nutrient requirement.*
Little One™ is a great option for those just starting on a multivitamin or for individuals looking to maintain health without the higher doses found in other formulas. It’s a more gentle option in a smaller capsule but still provides a full range of nutrients necessary for daily wellness.*
5. Metabolic Detox Complete® Powder
While not a traditional multivitamin, Metabolic Detox Complete® Powder is worth considering for those looking to support both nutrition and detoxification, with added protein. As a powder that can be mixed into food or beverages, it may also be a more suitable option for those do not prefer swallowing capsules.
This product provides a blend of essential vitamins and minerals, including methylated B vitamins, along with protein, fiber, and additional nutrients to support liver detoxification pathways.*
Metabolic Detox Complete® is ideal for those looking for additional liver support or individuals looking to combine their multivitamin intake with added protein and amino acids. It’s a convenient and comprehensive way to meet both micro and macro nutritional needs in one product.*
Please, always consult a healthcare practitioner before starting or changing a supplement regimen.
Final Thoughts
Choosing the right multivitamin is an important choice in supporting your overall health.* Whether you need basic foundational support or a more targeted multivitamin, we offers a range of high-quality, methylated multivitamin options to meet your needs. By selecting a product that contains methylated B vitamins, you ensure that your body can efficiently absorb and use the nutrients, maximizing your health benefits.*
Disclaimer:
The information provided is for educational purposes only. Consult your physician or healthcare practitioner if you have specific questions before instituting any changes in your daily lifestyle including changes in diet, exercise, and supplement use.
Laura Lewis is a clinical researcher and science communicator with a Master of Science degree and a background in nutrition science and integrative health. She brings a decade of experience translating complex clinical data into accessible insights for healthcare practitioners and patients alike.
Laura has contributed to educational programming and strategic content development across the integrative and functional medicine space. Her strengths lie in evidence synthesis, practitioner engagement, and crafting communications that bridge the gap between scientific rigor and real-world application. At ARG, Laura supports clinical content development and educational initiatives that elevate practitioner confidence and product credibility.