Clinical Rationale
Ovarian health is an important aspect of whole body health during women’s reproductive years. It can lead to a variety of clinical manifestations and physiological effects that typically involve many systems and organs.*
Level 1 Support
Healthy Estrogen Metabolism*: Choose one of the following
| Clarifying Clinical Objectives | Initial Trial of Supplement Support | Dose & Frequency | Duration & Rationale | Bottles Required for Trial | Clinical Re-evaluation & Monitoring | Partial Response |
| Premenstrual symptoms, menstrual regularity, support progesterone* |
DIM Vitex |
2 capsules once daily with meals | 16 weeks; clinical trials of Vitex agnus castus | Two 120 counts | Intensity, frequency, and duration (I/F/D) of PMS symptoms and menstrual regularity* | May increase to 2 capsules twice daily |
| High-normal luteinizing hormone (LH)* | 4 capsules daily with meals | 12 weeks; clinical trial of diindolylmeth- ane | Three 120 counts | I/F/D of PMS symptoms and menstrual regularity* | May increase to 4 capsules twice daily | |
| Balance androgens* | 2 softgels daily with meals | Four 60 counts | Three 60 counts or one 200 count | I/F/D of PMS symptoms and menstrual regularity* Objective changes in androgens* |
Add Nrf2 Renew® 2 capsules daily |
| Consider: Patients with persistent menstrual irregularities should be evaluated by gynecology and/or endocrinology and/or have a transvaginal ultrasound to rule out pathology. |
Metabolic Health*: Choose one or two of the following
| Clarifying Clinical Objectives | Initial Trial of Supplement Support | Dose & Frequency | Duration & Rationale | Bottles Required for Trial | Clinical Re-evaluation & Monitoring | Partial Response |
| Glucose regulation, balance lipids*^ |
Berberine 500 |
1 capsule two times daily with meals | 12 weeks; clinical trials of berberine | Two 90 counts | Objective changes in glucose or insulin parameters* | May increase to 2 capsules twice daily |
| Improve mood*^^ | Pregnenolone 100 | 1 tablet daily with a meal | 12 weeks; clinical trial of pregnenolone | Two 60 counts | I/F/D of mood changes* | May increase to 2-5 tablets daily |
| Improve working memory, balance androgens* | Advanced NeuroPlus® | 3 tablets daily with or without meals | 12 weeks; clinical trials of Mentha spicata | Three 90 counts | I/F/D of alertness or concentration* episodes Objective changes in androgens* |
Add Acetyl L-Carnitine 500 mg 2 capsules daily |
^ within normal limits ^^ report of, Patient Health Questionnaire (PHQ-9), Depression Anxiety Stress Scale (DASS-21)
Assessment Tools
- Questionnaires: PCOS Health-Related Quality of Life Questionnaire (PCOSQ), Premenstrual Symptoms Screening Tool (PSST)
- Biochemical testing: Glucose, insulin, hemoglobin A1c, lipid panel, total and free testosterone, estradiol, luteinizing hormone and follicle stimulating hormone
Level 2 Support
| Further Evaluation | Potential Assessments | Products to Consider |
| Thyroid function* | TSH Free T3, Free T4 Thyroid antibodies |
|
| Stress response* | Perceived Stress Scale Cortisol | Adrenal Glandular |
| Mood and sleep* | GAD-7 Pittsburgh Sleep Quality Index (PSQI) Epworth Sleepiness Scale (ESS) | Zen Adapt Zen Sleep |
| Upper gastric function* | GerdQ |
Mastica® Ox Bile 500 mg |
| Detoxification pathways* | ALT and AST | Milk Thistle Plus |
|
Microbiome/ intestinal support* |
Intestinal permeability | Essential-Biotic® Saccharomyces Boulardii |
| Immune function* | CBC Functional stool/ microbiome analysis |
Tricycline® ImmunoBiotic Pro |
| Allies (start/optimize): ✓ Incorporate more low glycemic index foods ✓ Adequately hydrate ✓ Stress management techniques ✓ Sleep hygiene ✓ Moderate-vigorous exercise |
| Foes (avoid/minimize): ⓧ Inflammatory foods ⓧ Environmental toxins ⓧ Smoking ⓧ Alcohol |
| Foundational Support: □ Vitamin D3 Complete 5000 □ Magnesium Citrate □ Super □ EPA Buffered Vitamin C □ Super Vitamin B |
The information contained herein is for training purposes only to be exclusively used by a qualified healthcare professional.
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.